FUSION PROTEIN COMPRISING MODIFIED ANTI-VEGFR2 (KDR) ANTIBODY AND USE THEREOF

Abstract: the present invention relates to a fusion protein comprising a modified anti-vegfr2 (kdr) antibody having improved properties or an antigen-binding fragment thereof, and a use thereof. specifically, the present invention pertains to a fusion protein, and a composition for diagnosis or treatment of an angiogenesis-associated disease, a composition for prevention or treatment of a tumor or cancer, and a composition for administration in combination with a therapeutic agent other than the fusion protein, each composition comprising the fusion protein, wherein the fusion protein has an anti-vegfr2(kdr) antibody conjugated with a delta-like ligand 4 (dll4)-binding protein domain at the terminus thereof, the anti-vegfr2(kdr) antibody being derived from a human antibody binding specifically to vegfr2/kdr by substituting vh1 in the heavy chain framework region (fr) with vh3 and vl1 in the light chain framework region (fr) with vk1 and inducing a mutation therein, thereby increasing the affinity of the antibody for the antigen.

Inventor(s): Ju Ryoung NAM, Youngae LEE, Weon Sup LEE, Jin-San YOO

CPC Classification: C07K16/2863 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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