Integrin Alpha10 Antibody

Abstract: the present invention relates to a novel integrin alphalo antibody, as well as uses thereof in medicine. 25 humanized antibodies (abs) derived from the known mouse mab365 (the hybridoma deposited under the accession number dsm acc2583) are disclosed. the ones which bind specifically the integrin alpha 10 beta 1 were selected. out of the 25 humanized variants 5 were selected as lead candidates (designated tar-ab8, tar-ab9, tar-abl3, tar-abl4 and tar-ab23) since these 5 entire antibodies were shown to have improved thermal stability as compared to the chimeric antibody designated tar-ab0. there is further functional characterization only of tar-ab23 which has higher binding affinity than mab365.

Inventor(s): Evy Lundgren Åkerlund, Katarzyna Chmielarska Masoumi, Xiaoli Huang

CPC Classification: C07K16/2842 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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