SARS-COV-2 NEUTRALIZING SYNTHETIC PROTEINS

Abstract: the present disclosure relates to compositions and methods for the treatment and/or prevention of sars-cov-2 infections. in one embodiment the method comprises the delivery of a pharmaceutical composition comprising a sars-cov-2 neutralizing synthetic protein, optionally wherein the protein is a trimeric protein composed of designed ankyrin repeat protein (darpin) fused with a t4 foldon peptide that is administered non-invasively such as by nasal inhalation.

Inventor(s): Zhilei CHEN, Vikas CHONIRA, Rudo SIMEON

CPC Classification: C07K16/1003 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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