FUSION PROTEIN OF GLP-1 AND GDF15 AND USE THEREOF

Abstract: a fusion protein of glp-1 and gdf15 and the use thereof. the fusion protein comprises a first polypeptide fragment, a second polypeptide fragment and a third polypeptide fragment which are sequentially connected from an amino terminal to a carboxyl terminal; and the three polypeptide fragments sequentially comprise a glp-1 polypeptide, an immunoglobulin fc region and a gdf15 active domain. the fusion protein provided has a glp-1 and gdf15 dual-target activity. the fusion protein as a whole has excellent physicochemical properties and stability, and the two target molecules of glp-1 and gdf15 have a good activity and pharmacokinetic balance, facilitating the exertion of a dual-target effect.

Inventor(s): Jiangyu YAN, Lin XIAO, Junnan ZENG, Qingwei GONG, Xiaoli CHENG, Xiaoying LIU, Wenjia LI

CPC Classification: C07K14/605 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

Search for rejections for patent application number 20250179142