20250179124. Beta-catenin Protein Degradation (UbiquiTx)
BETA-CATENIN PROTEIN DEGRADATION
Abstract: an isolated chimeric molecule is provided comprising: (i) a degradation domain comprising an e3 ubiquitin ligase motif without lysine residues; (ii) a targeting domain comprising a substrate-binding motif which is heterologous to the e3 ubiquitin ligase motif and configured to bind to beta-catenin; and (iii) a linker coupling said degradation domain to said targeting domain.
Inventor(s): Pranam CHATTERJEE, Suhaas BHAT, Kalyan PALEPU, Matthew DELISA, Tina YE
CPC Classification: C07K14/001 ({by chemical synthesis})
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