20250179077. Quinazoline Compounds Uses Ther (AMGEN .)
QUINAZOLINE COMPOUNDS AND USES THEREOF AS INHIBITORS OF MUTANT KRAS PROTEINS
Abstract: the present disclosure provides compounds useful for the inhibition of kras g12d, g12v, g12a, g12s or g12c. the compounds have a general formula (i): (formula (i)) wherein the variables of formula (i) are defined herein. this disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.
Inventor(s): Brian Alan Lanman, Ryan Paul Wurz, Wei Zhao, Xiaofen LI, Imelda HOT, Rene RAHIMOFF, Liping Pettus, Ning Chen, Fabien EMMETIERE, Jeffery Jackson, Yunxiao LI, Francesco Manoni, Primali Navaratne, Andrew Smaligo, John Charles Stellwagen, John Allen
CPC Classification: C07D487/04 (Ortho-condensed systems)
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- Patent Applications
- AMGEN INC.
- CPC C07D487/04
- Brian Alan Lanman of Woodland Hills CA US
- Ryan Paul Wurz of Newbury Park CA US
- Wei Zhao of Westford MA US
- Xiaofen LI of Thousand Oaks CA US
- Imelda HOT of Thousand Oaks CA US
- Rene RAHIMOFF of Santa Monica CA US
- Liping Pettus of Thousand Oaks CA US
- Ning Chen of Thousand Oaks CA US
- Fabien EMMETIERE of Thousand Oaks CA US
- Jeffery Jackson of Thousand Oaks CA US
- Yunxiao LI of Thousand Oaks CA US
- Francesco Manoni of Newbury Park CA US
- Primali Navaratne of Thousand Oaks CA US
- Andrew Smaligo of Thousand Oaks CA US
- John Charles Stellwagen of Newbury Park CA US
- John Allen of Newbury Park CA US