Deuterium-Enriched 3,5-Dimethylpyrazolyl-3-propoxy-4-fluorobenzoic Acids for Treatment of Transthyretin Amyloidosis Cardiomyopathy (ATTR-CM) and Polyneuropathy (ATTR-PN), and Related Diseases

Abstract: the present invention is concerned with novel deuterium-enriched compounds of the general chemical structural formula i, and pharmaceutically acceptable salts, compositions, and methods of use thereof, wherein, r is independently deuterium (d), hydrogen (h) atom. compounds of the general chemical structure formula i are stabilizers of the transthyretin (ttr) protein and are useful in the treatment of transthyretin amyloidosis cardiomyopathy (attr-cm) and polyneuropathy (attr-pn), and related diseases.

Inventor(s): DALJIT SINGH DHANOA

CPC Classification: C07D231/12 (HETEROCYCLIC COMPOUNDS (macromolecular compounds ))

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