PSMA TARGETED RADIOHALOGENATED UREA-POLYAMINOCARBOXYLATES FOR CANCER RADIOTHERAPY

Abstract: small molecule radiohalogenated psma inhibitors and metal complexes thereof and their use in radioimaging and radiotherapy for treating psma-related diseases, including prostate cancer, are disclosed. the combination of small molecule radiohalogenated psma inhibitors with a competitive psma ligand for reducing off-target accumulation of the radiohalogenated psma inhibitor also is disclosed.

Inventor(s): Martin G. Pomper, Ronnie C. Mease, Vivek Kumar, Sangeeta Ray, Michael Zalutsky, Ganesan Vaidyanathan

CPC Classification: A61K51/0482 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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