RETROVIRAL VECTORS

Abstract: this invention relates to retroviral gene transfer vectors, particularly lentiviral vectors, pseudotyped with hemagglutinin-neuraminidase (hn) and fusion (f) proteins from a respiratory paramyxovirus, comprising a promoter and a transgene; and methods of making the same. the present invention also relates to the use of said vectors in gene therapy, particularly for the treatment of respiratory tract diseases such as cystic fibrosis (cf).

Inventor(s): Deborah R. Gill, Stephen C. Hyde

CPC Classification: A61K48/0075 (Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy)

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