Adeno-Associated Viral (AAV)-Mediated Sphingosine-1-Phosphate Lyase (SPL) Expression for Treating Pulmonary Fibrosis

Abstract: the present disclosure provides methods treating or preventing pulmonary fibrosis in a subject in need thereof by administering to the subject a therapeutically effective dose of a recombinant adeno-associated viral (raav) virion comprising a nucleic acid encoding sphingosine-1-phosphate lyase (spl), where administering the raav virion results in expression of the spl in the subject thereby treating or preventing the pulmonary fibrosis in the subject.

Inventor(s): Julie D. Saba, Mallar Bhattacharya

CPC Classification: A61K48/005 (Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy)

Search for rejections for patent application number 20250177563