FUSOGENIC PEPTIDE COMPOSITIONS AND METHODS OF CARGO DELIVERY

Abstract: the present invention is based on the identification of fusogenic polypeptides that not only enhance cellular uptake, but also enhance the fusogenicity of the polypeptides to cause endosomal membrane destabilization, resulting in permeabilization and release of a cargo into the cytosol. thus, one aspect of the invention relates to a fusogenic polypeptides having a peptide sequence with amphipathic properties and a peptide sequence having multiple positively charged amino acid residues for the binding of a cargo. a further aspect of the invention relates to methods using the fusogenic polypeptides for delivery of cargo into a cell.

Inventor(s): Timothy SAMEC, Angela ALEXANDER-BRYANT, K. Lora ALATISE

CPC Classification: A61K47/6807 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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