MULTISPECIFIC ANTIGEN-BINDING PROTEINS

Abstract: provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the vh/vl domains and/or ch1/cl domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.

Inventor(s): Paul CARTER, Christoph SPIESS, Yiyuan YIN, Jianhui ZHOU, Wendy SANDOVAL, Jacob CORN, Michael DILLON

CPC Classification: A61K39/44 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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