METHODS FOR PRODUCING AN ADJUVANT

Abstract: this invention provides methods for producing homogeneous and heterogeneous adjuvant formulations comprising a liposome bilayer comprising (a) monophosphoryl lipid a (mpla), (b) a saponin, and (c) a liposome composition comprising (i) at least one phospholipid selected from phosphatidylcholine (pc) and/or phosphatidylglycerol (pg), wherein the phospholipid is selected from the group consisting of dimyristoyl phosphatidylcholine (dmpc), dipalmitoyl phosphatidylcholine (dppc), distearyl phosphatidylcholine (dspc), dimyristoyl phosphatidylglycerol (dmpg), dipalmitoyl phosphatidylglycerol (dppg), distearyl phosphatidylglycerol (dspg), and a combination thereof, and (ii) cholesterol wherein the mole percent concentration of the cholesterol in the liposome composition is greater than 50% (mol/mol), and further provides the adjuvant formulations produced from said methods.

Inventor(s): Parisa Ansari, Advait Vijay Badkar, Leena Shriram Bagle, Zoltan Beck, Bo Chen, Ramin Darvari, Parag Ashok Kolhe, Maria Sergeyevna Lapshina, Rachna Gopalkrishna Nayak, Naveen Palath, Shuai Shi

CPC Classification: A61K39/39 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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