METHODS FOR ADMINISTERING FREEZE-DRIED PLATELET DERIVATIVE COMPOSITIONS TO SUBJECTS TREATED WITH A FACTOR XI INHIBITOR

Abstract: provided herein are compositions comprising platelet derivatives, and methods for administering the same to a subject in need thereof. also provided herein are methods and compositions for reducing bleeding in a subject. such methods can include administering to the subject in need thereof, for example because they have been or are being treated with an anticoagulant agent, for example, a factor xi inhibitor, and/or an antiplatelet, a dose of rehydrated platelet derivative composition comprising platelet derivatives. various properties of exemplary embodiments of such methods and platelet derivatives used therein, as well as numerous additional aspects and embodiments are provided herein.

Inventor(s): Keith Andrew MOSKOWITZ, Braden Carl ISHLER, William Matthew DICKERSON, Amber Nicole LEE, Shan XU, Stephen Edward AMOS, Rafael JORDA, Michael Alexander MATHEWS

CPC Classification: A61K35/19 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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