PHARMACEUTICAL COMPOSITION FOR TREATING TUMORS

Abstract: the present invention provides a pharmaceutical composition for treating a tumor, the pharmaceutical composition comprising (6s,9as)-n-benzyl-8-({6-[3-(4-ethylpiperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxo-2-(prop-2-en-1-yl)hexahydr o-2h-pyrazino[2,1-c][1,2,4]triazine-1(6h)-carboxamide represented by formula (i) or a pharmaceutically acceptable salt thereof, wherein the pharmaceutical composition is administered in combination with an ras inhibitor.

Inventor(s): Yu Kato, Masahiko Kume, Yusaku Hori, Yusuke Adachi

CPC Classification: A61K31/53 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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