ALPHA 2 ADRENERGIC RECEPTOR BLOCKADE FOR THE TREATMENT OF C. DIFFICILE COLITIS

Abstract: provided are methods and compositions for treating and/or preventing infections, particularly recurring infections. the compositions for use in treating and/or preventing infections include in some embodiments at least one agent that inhibits an alpha 2 adrenergic receptor, and the presently disclosed methods include administering at least one such composition to a subject in need thereof, optionally in combination with other therapeutically active agents including but not limited to an enhancer of an il-13 biological activity, optionally an il-13 peptide or a fragment or homolog thereof; an interleukin-13 receptor subunit alpha-2 (il-13ra2) inhibitor; an enhancer of an interleukin-33 (il-33) biological activity, optionally an il-33 polypeptide or a biologically active fragment or homolog thereof; or any combination thereof.

Inventor(s): William A. Petri, Jr., David Tyus

CPC Classification: A61K31/4745 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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