FORMULATION OF INTRINSICALLY ACID-RESISTANT VEGETARIAN-BASED AND GELATIN-BASED SOFT GEL CAPSULES FOR PHARMACEUTICAL/ NUTRACEUTICAL PRODUCTS

Abstract: a method of manufacturing an enteric gel capsule and the enteric gel capsules produced by this method. the method of manufacturing the enteric gel capsule involves: dissolving a gelling polymer and a plasticizer into water to form an polymer mixture; mixing a bulk amount of acid insoluble polymer dispersion with a calculated amount of alkali agent to form a bulk amount of translucent acid insoluble polymer dispersion, the amount of alkali agent determined from a titration curve prepared by titrating a sample of the acid insoluble polymer; and adding the bulk amount of translucent acid insoluble polymer dispersion to the polymer mixture while mixing and heating at 70� c. until a gel mass forms.

Inventor(s): Farzad Kobarfard, Marjan Esfahanizadeh, Arash Lotfi Seisan, Hooshang Lotfisisan

CPC Classification: A61K9/4825 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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