HYPOTONIC GEL-FORMING FORMULATIONS WITH ENHANCED RHEOLOGICAL PROPERTIES

Abstract: improved hypotonic gelling vehicles are described as solubilizing agents for drugs and as a means to provide sustained drug delivery to the eye. it has been discovered that the addition of small amounts of low molecular weight peg to hypotonic gel-forming compositions enhances the viscosity of the solution at the ocular surface, prologs tear break-up time and increases ocular comfort. solubilizing drugs at higher concentrations enhances drug penetration into the tissues of the body, while the hypotonic gelling vehicle further improves distribution of the drug over a larger surface area for increased absorption and sustained release for reduced side effects and longer duration of action.

Inventor(s): Laura Ensign, Tung Heng Henry Hsueh, Justin Hanes

CPC Classification: A61K9/0048 (Medicinal preparations characterised by special physical form {(nuclear magnetic resonance contrast preparations or magnetic resonance imaging contrast preparations ; preparations containing radioactive substances )})

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