SYSTEMS AND METHODS FOR SENSING LEVODOPA

Abstract: a levodopa-selective sensor is provided. a continuous levodopa monitor is also provided. the levodopa sensor includes a sensor area having a working electrode with a levodopa-selective chemistry configured for at least partial implantation in a host. the sensor also includes at least one membrane adjacent the levodopa-selective chemistry. the at least one membrane includes an enzyme domain that at least one enzyme selected from a tyrosinase; a mutated tyrosinase with specificity towards --dihydroxyphenylalanine; a dihydroxyphenylalanine 4,5-dioxygenase; a mutated dihydroxyphenylalanine 4,5-dioxygenase with specificity towards 1-3,4-dihydroxyphenylalanine; and combinations thereof; a synthase enzyme with specificity towards 1-3,4-dihydroxyphenylalanine; a mutated synthase enzyme with specificity towards 1-3,4-dihydroxyphenylalanine; a 3,4-dihydroxyphenyl-acetaldehyde synthase; a mutated 3,4-dihydroxyphenyl-acetaldehyde synthase with specificity towards 1-3,4-dihydroxyphenylalanine; a dioxygenase enzyme with specificity towards 1-3,4-dihydroxyphenylalanine; and a mutated dioxygenase enzyme with specificity towards 1-3,4-dihydroxyphenylalanine.

Inventor(s): Hifza Najib, Joshua Ray Windmiller, Rebekah Pattison Dyer, Eva Vargas Orgaz, Nai-Jen Chang, Jie Zhu, Matthew Scott Brown, Jiong Zou

CPC Classification: A61B5/14546 (Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; {Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue} (measuring of blood pressure or blood flow ; non-radiation detecting or locating of foreign bodies in blood ))

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