PEPTIDE QUANTITATION ASSAY FOR DIFFERENTIATING FULL-LENGTH HIGH MOLECULAR WEIGHT KININOGEN (HMWK) AND CLEAVED HMWK

Abstract: methods for differentiating full-length high molecular weight kininogen (hmwk) and cleaved hmwk in a sample are provided herein. such methods may comprise treating a biological sample with a protease to generate a plurality of digested peptides, and measuring one or more signature peptides, which are indicative of cleaved hmwk and/or full-length hmwk.

Inventor(s): Jiang Wu, Guodong Zhang, Daniel J. Sexton, Ryan Faucette, Gul M. Mustafa, Mark Szewc

CPC Classification: G01N33/6848 ({Methods of protein analysis involving mass spectrometry})

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