USE OF CD38+HLA-DR+CD8+ T CELL IN EARLY DIAGNOSIS OF ACUTE GRAFT-VERSUS-HOST DISEASE

Abstract: provided are a detection reagent for acute graft-versus-host disease (agvhd) and the use of the percentage of cd38hladrcd8 t cell as a biomarker for agvhd. the present application has unexpectedly found that a proportion of the cd38hladrcd8 t cell in peripheral blood of a patient with agvhd is significantly greater than that in peripheral blood of a healthy donor and a patient without agvhd after transplantation. the receiver operating characteristic (roc) curve analysis shows that the cd38hladrcd8 t cell has an area under the roc curve (auc) of 0.84, with a sensitivity of 80.8%, and a specificity of 75.0% when used in early diagnosis of agvhd. results indicate that the cd38hladrcd8 t cell is a marker for early diagnosis of agvhd with a prominent diagnostic effect. the marker can guide the clinical medication.

Inventor(s): Yufeng Liu, Jie Cao, Limei Zhong, Yinchun Chen, Ruiqing Zhou, Shunqing Wang, Wenjian Mo

CPC Classification: G01N33/56972 (for microorganisms, e.g. protozoa, bacteria, viruses)

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