20250172547. Multivalent Binding (Element Biosciences, .)
MULTIVALENT BINDING COMPOSITION FOR NUCLEIC ACID ANALYSIS
Abstract: multivalent binding compositions including a particle-nucleotide conjugate having a plurality of copies of a nucleotide attached to the particle are described. the multivalent binding compositions allow one to localize detectable signals to active regions of biochemical interaction, e.g., sites of protein-protein interaction, protein-nucleic acid interaction, nucleic acid hybridization, or enzymatic reaction, and can be used to identify sites of base incorporation in elongating nucleic acid chains during polymerase reactions and to provide improved base discrimination for sequencing and array based applications.
Inventor(s): Michael PREVITE, Molly HE, Junhua ZHAO, Hui Zhen MAH, Chunhong ZHOU, Sinan ARSLAN, Matthew KELLINGER, Lorenzo BERTI, Steve Xiangling CHEN
CPC Classification: G01N33/5308 ({for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites})
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- Patent Applications
- Element Biosciences, Inc.
- CPC G01N33/5308
- Michael PREVITE of San Diego CA US
- Molly HE of San Diego CA US
- Junhua ZHAO of San Diego CA US
- Hui Zhen MAH of San Diego CA US
- Chunhong ZHOU of San Diego CA US
- Sinan ARSLAN of San Diego CA US
- Matthew KELLINGER of San Diego CA US
- Lorenzo BERTI of San Diego CA US
- Steve Xiangling CHEN of San Diego CA US