METHODS OF DETECTING ANALYTES

Abstract: localized detection of rna in a tissue sample that includes cells is accomplished on an array. the array include a number of features on a substrate. each feature includes a different capture probe immobilized such that the capture probe has a free 3′ end. each feature occupies a distinct position on the array and has an area of less than about 1 mm. each capture probe is a nucleic acid molecule, which includes a positional domain including a nucleotide sequence unique to a particular feature, and a capture domain including a nucleotide sequence complementary to the rna to be detected. the capture domain can be at a position 3′ of the positional domain.

Inventor(s): Jonas Frisen, Patrik Stahl, Joakim Lundeberg

CPC Classification: C12Q1/6837 (using probe arrays or probe chips ( takes precedence))

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