CATALYST-FREE SURFACE FUNCTIONALIZATION AND POLYMER GRAFTING

Abstract: some embodiments described herein relate to a substrate with a surface comprising a silane or a silane derivative covalently attached to optionally substituted cycloalkene or optionally substituted heterocycloalkene for direct conjugation with a functionalized molecule of interest, such as a polymer, a hydrogel, an amino acid, a nucleoside, a nucleotide, a peptide, a polynucleotide, or a protein. in some embodiments, the silane or silane derivative contains optionally substituted norbornene or norbornene derivatives. method for preparing a functionalized surface and the use in dna sequencing and other diagnostic applications are also disclosed.

Inventor(s): Lorenzo Berti, Andrew A. Brown, Wayne N. George

CPC Classification: C08J7/12 (Chemical modification)

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