Bispecific Constructs for Target and Complement Engagement

Abstract: single domain antibodies are provided, which are capable of specifically binding to an epitope of a human complement factor selected from the group consisting of c1q, c3, c4 and/or the proteolytic derivatives c3b and c4b. further the use of the antibodies are provided for methods in modulating the activity of the complement system as well as methods of treating disorders associated with complement activation.

Inventor(s): Nick Stub Laursen, Dennis Vestergaard Pedersen, Gregers Rom Andersen, Steffen Thiel, Alessandra Zarantonello, Rasmus Kjeldsen Jensen, Henrik Pedersen

CPC Classification: C07K16/2896 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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