N-TERMINAL scFv MULTISPECIFIC BINDING MOLECULES

Abstract: multispecific binding molecules (mbms) comprising an n-terminal scfv, a first fab and a second fab, mbm conjugates comprising the mbms and cytotoxic or cytostatic agents, pharmaceutical compositions containing the mbms and mbm conjugates, methods of using the mbms, mbm conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the mbms, cells engineered to express the mbms, and methods of producing mbms.

Inventor(s): Yang SHEN, Ann-Hwee LEE, Yan YANG, Chia-Yang LIN

CPC Classification: C07K16/2863 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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