MONOCLONAL ANTIBODY AGAINST HLA-G MOLECULES AND USE THEREOF

Abstract: an antibody ywhg-1 against hla-g molecule and use thereof. the antibody is produced by the hybridoma deposited under cctcc no: 202120, and is prepared by an immunogen with amino acids which are common to seven known hla-g isoforms (hla-g1, hla-g2, hla-g3, hla-g4, hla-g5, hla-g6 and hla-g7) which is located at positions 72-91 (qtdrmnlqtlrgyynqseas) (seq id no: 19) in the heavy chain al domain of the hla-g molecule. nucleotides encoding the antibody ywhg-1 and encoded amino acid sequences thereof are provided as well. the antibody ywhg-1 can be used for immunohistochemistry, immunoblotting, flow cytometry and other assays for hla-g isoforms.

Inventor(s): Weihua YAN

CPC Classification: C07K16/2833 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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