TREATING CANCER BY BLOCKING THE INTERACTION OF TIM-3 AND ITS LIGAND

Abstract: provided herein are methods of activating immune response and/or treating cancer in a patient comprising administering to the patient a gal3:tim-3 inhibitor that interferes with the interaction between gal3 and tim-3, where said inhibitor is administered in an amount sufficient to activate immune response. also provided are a humanized anti-gal3 antibodies that can block the interaction between gal3 and tim3 and methods of using the anti-gal3 antibody to treat cancer. methods for determining if a patient's cancer is suitable for treatment with a gal3:tim-3 inhibitor and methods for selecting compounds that can block interaction between gal3 and tim-3, activating immune response and/or treating cancer are also provided.

Inventor(s): Dongxu Sun, Yan Wang

CPC Classification: C07K16/2803 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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