TIM-3 ANTAGONISTS FOR THE TREATMENT AND DIAGNOSIS OF CANCERS

Abstract: provided herein are methods for treating a subject afflicted with a cancer, comprising administering to the subject a tim3 agonist (e.g., an anti-tim3 antibody), alone or in conjunction with another immune checkpoint inhibitor (e.g., a pd-1 antagonist), wherein the subject is identified as having a high frequency of tim3 positive cells (e.g., on the tumor infiltrating inflammatory cells) or soluble tim3 in peripheral blood. also provided are methods for assessing the efficacy of a treatment comprising a tim3 antagonist in a subject afflicted with a cancer, comprising measuring the frequency of tim3 (and optionally pd-1) positive cells in certain populations of cells and/or the soluble tim3 in peripheral blood of the subject, wherein a high frequency of tim3 (and optionally pd-1) positive cells and/or the subject's peripheral blood titer of soluble tim3 is indicative of the response to the treatment.

Inventor(s): Anke KLIPPEL, Laurence Celine MENARD

CPC Classification: C07K16/2803 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

Search for rejections for patent application number 20250171538