METHOD OF TREATING DISEASE USING ANTI-CD47 X ANTI-MESOTHELIN ANTIBODIES AS A SOLE AGENT AND IN COMBINATION WITH ANTI-PD-1 ANTIBODIES

Abstract: the invention relates method of treatment of cancer using novel bispecific antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, where one of the binding sites is specific for cd47 and the second is specific for mesothelin (msln). in addition, the disclosure contains methods of treatment using novel bispecific antibodies in combination with anti-pd-1 antibody.

Inventor(s): Jose Maria SARO SUAREZ, Walter G. FERLIN

CPC Classification: C07K16/2803 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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