COMPOSITIONS AND METHODS FOR DEPLETION OF DISEASED HEMATOPOIETIC STEM CELLS

Abstract: provided herein are compositions and methods related to depletion of diseased hematopoietic stem cells (hsc) using an anti-c-kit antibody. the compositions and methods described herein may be used to treat a subject in need of diseased hsc depletion due to a variety of diseases or disorders, such as myelodysplastic syndrome and acute myeloid leukemia.

Inventor(s): Wendy PANG, Hye-Sook KWON

CPC Classification: C07K16/2803 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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