PEPTIDE ACIDS AS A GLP1R AGONIST AND ANTIBODY-DRUG CONJUGATES THEREOF

Abstract: described herein are protein-drug conjugates and compositions thereof that are useful, for example, for targeting glucagon-like peptide 1 receptor (glp1r). in certain embodiments, provided are peptidomimetic payloads and linker-payloads and methods of making same. more specifically, glp1 peptidomimetics, antibody-drug conjugates, and compositions which comprise anti-glp1r antibodies and glp1 peptidomimetic payloads and methods of treating glp1r-associated conditions are provided.

Inventor(s): Amy HAN, Xiang Zheng, William Olson, Andrew J. Murphy, Frank Delfino, Haruka Okamoto, Jean Yanolatos, Huachuan Cao, Mark W. Sleeman

CPC Classification: C07K14/605 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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