METHOD FOR SYNTHESIZING PEPTIDE CONTAINING N-SUBSTITUTED AMINO ACID

Abstract: methods of producing a peptide containing an n-substituted amino acid or n-substituted amino acid analog of the present invention include the steps of: preparing an fmoc-protected amino acid, an fmoc-protected amino acid analog, or an fmoc-protected peptide; deprotecting a protecting group which have an fmoc skeleton of the fmoc-protected amino acid and such by using a base; and forming an amide bond by adding a new fmoc-protected amino acid and such; and when the peptide is produced by a solid-phase method, the obtained peptide is cleaved off from the solid phase under conditions of weaker acidity than tfa. furthermore, at least one side chain of the obtained peptide has a protecting group that is not deprotected under basic conditions and is deprotected under conditions of weaker acidity than tfa.

Inventor(s): Kenichi NOMURA, Terushige MURAOKA, Mikimasa TANADA, Takashi EMURA

CPC Classification: C07K1/061 (using protecting groups or activating agents {(, take precedence)})

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