SYNTHESIS OF PHOSPHATE DERIVATIVES

Abstract: the present invention is a process for the preparation of certain 5′-phosphoramidate nucleotide diastereoisomers. the phosphoramidates include those useful in the treatment of cancer such as nuc-3373 (5-fluoro-2′-deoxyuridine-5′-o-[1-naphthyl(benzyloxy-l-alaninyl)]phosphate].

Inventor(s): Hugh Griffith, Gordon Kennovin, Venkata Lakshmi Narasimha Rao Dammalapati, Mani Bushan Kotala

CPC Classification: C07H19/207 (the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide)

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