HUMANIZED ANTI-TISSUE FACTOR ANTIBODY, ANTIBODY-DRUG CONJUGATE PREPARED THEREFROM AND USE THEREOF

Abstract: provided is a humanized anti-tissue factor antibody, an antibody-drug conjugate prepared therefrom and use thereof. the humanized anti-tissue factor antibody has high affinity to tissue factor. also provided is an antibody-drug conjugate, which is obtained by coupling the humanized anti-tissue factor antibody to a cytotoxic drug. based on the humanized anti-tissue factor antibody, which has high affinity and short endocytosis time for tumor cells with low-and high-expression of tissue factor, the antibody-drug conjugate can quickly reach the target site of the tumor and exert a cytotoxic effect. the humanized anti-tissue factor antibody can effectively inhibit the growth of tumor cells and the growth of subcutaneous tumors in mice. therefore, the antibody-drug conjugate of the present disclosure plays an important role in cancer therapy.

Inventor(s): Zhican QU, Yi ZHAO, Xin YANG, Quanai ZHANG, Weiwei PAN, Xinxin LIANG, Jianli LI, Huahua HAO

CPC Classification: A61K47/68031 ({Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates})

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