ENGINEERED IMMUNOMODULATORY ACCESSORY CELLS IMPROVE ALLOGENEIC ISLET TRANSPLANTATION WITHOUT IMMUNOSUPPRESSION

Abstract: disclosed herein are recombinant mesenchymal stromal cells (e mscs) that expresses one or more immunomodulatory proteins or polypeptides as well as mixed cell populations that include the emscs and one or more cell types distinct of the emsc, such as islet cells or islets. also disclosed are implantable cell culture devices that include emscs or the mixed cell populations. the emscs can be used to improve survival of transplanted cells (such as an allograft), and more particularly to methods of modifying t cell response to an allograft and treating a diabetic subject.

Inventor(s): Minglin MA, Xi WANG, Bo WANG

CPC Classification: A61K35/28 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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