20250163500. Methods Devices Spati (AtlasXomics .)

METHODS AND DEVICES FOR SPATIALLY ENCODED BIOLOGICAL ASSAYS

Abstract: the present disclosure generally relates to methods for increasing the region of interest of spatial multi-omics techniques while retaining single-cell resolution. these methods can improve the scaling of region of interest dimension with input/output channels from linear to super-linear. in some embodiments, the method is performed by providing a plurality of probes of a first type to a first region of a sample, wherein at least a subset of the probes of the first type includes a first spatial barcode, providing a plurality of probes of a second type to a second region of the sample, wherein at least a subset of the probes of the second type includes a second spatial barcode, and providing a probe of a third type to a third region of the sample, wherein the probe of the third type comprises a third spatial barcode.

Inventor(s): Joseph C. GENNARO

CPC Classification: C12Q1/6832 (Enhancement of hybridisation reaction)

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