COVALENTLY SURFACE MODIFIED ADENO-ASSOCIATED VIRUS PRODUCTION BY IN VITRO CONJUGATION, AND PURIFICATION OF COVALENTLY SURFACE MODIFIED ADENO-ASSOCIATED VIRUS

Abstract: the present inventions provide covalently surface modified adeno-associated viruses can comprise genes of interest (gois) and advantageously can be targeted to certain cell and tissue types for preventative and therapeutic purposes. the covalently surface modified adeno-associated viruses also can be mutated to detarget certain tissues and organs, such as the liver. the present inventions further provide systems and methods for engineering adeno-associated virus (aav) to create covalently surface modified adeno-associated viruses, and methods of purifying such covalently surface modified adeno-associated viruses. the inventions further include covalently surface modified adeno-associated viruses and preparations and products comprising such covalently surface modified adeno-associated viruses.

Inventor(s): Garima Thakur, Zhe Zhang, Sheldon Robert Mink, Andrew David Tustian

CPC Classification: C12N15/86 (MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media ))

Search for rejections for patent application number 20250163468