20250163392. Nucleic Acid-guided Nickase Fu (Inscripta, .)

NUCLEIC ACID-GUIDED NICKASE FUSION PROTEINS

Abstract: this disclosure provides compositions and methods useful for editing a target nucleic acid molecule. this disclosure provides mad2019-h848a variant polypeptides, reverse transcriptases, and fusion proteins and methods of using mad2019-h848a variant polypeptides, reverse transcriptases, and fusion proteins to edit nucleic acid molecules both in vivo and in vitro.

Inventor(s): Juhan Kim, Benjamin Mijts

CPC Classification: C12N9/1276 (MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media ))

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