HUMANIZED BCMA ANTIBODY AND BCMA-CAR-T CELLS

Abstract: the present invention is directed to a humanized bcma single-chain variable fragment (scfv), comprising vhaving the amino acid sequence of seq id no: 3 and vhaving the amino acid sequence of seq id no: 5. the present invention is also directed to a bcma chimeric antigen receptor fusion protein comprising from n-terminus to c-terminus: (i) a single-chain variable fragment (scfv) of the present invention, (ii) a transmembrane domain, (iii) at least one co-stimulatory domains, and (iv) an activating domain. this humanized bcma-car-t cells have specific killing activity against bcma-positive tumor cells.

Inventor(s): Vita Golubovskaya, Lijun Wu

CPC Classification: C07K16/2878 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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