NOVEL MONOCLONAL ANTIBODIES TO CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED PROTEIN 4 (CTLA-4)

Abstract: the present invention provides ctla-4 monoclonal antibodies, particularly humanized monoclonal antibodies specifically binding to ctla-4 with high affinity. the present invention also provides functional monoclonal antibodies cross-reactive to ctla-4 of human, cynomolgus monkey and mouse. the present invention further provides amino acid sequences of the antibodies of the invention, cloning or expression vectors, host cells and methods for expressing or isolating the antibodies. the epitopes of the antibodies are identified. therapeutic compositions comprising the antibodies of the invention are also provided. the invention also provides methods for treating cancers and other diseases with anti-ctla-4 antibodies.

Inventor(s): Zhuozhi Wang, JIng Li, Gennady Gololobov, Jianqing Xu

CPC Classification: C07K16/2818 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

Search for rejections for patent application number 20250163156