HYDROPHOBIC INTERACTION CHROMATOGRAPHY FOR VIRAL CLEARANCE

Abstract: the present application provides a method for characterizing and/or determining viral clearance capacity of hydrophobic interaction chromatography (hic) including experimental design for multivariate analysis of viral clearance of hic. the method provides understanding of the mechanism of the viral clearance using hic by running a d-optimal design of experiment including evaluations of multiple factors, such as ph, buffer concentration, column loading concentration, flow rate of column, or hydrophobic strength of the hic column.

Inventor(s): John Ruppino, John Mattila, Robert Stairs

CPC Classification: C07K16/065 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

Search for rejections for patent application number 20250163134