T CELL EXPRESSING AN FC GAMMA RECEPTOR AND METHODS OF USE THEREOF

Abstract: a t cell expressing an fc gamma receptor is provided. accordingly there is provided a t cell genetically engineered to express a first polypeptide comprising an amino acid sequence of an fc receptor common � chain (fcr�), said amino acid sequence is capable of transmitting an activating signal; and a second polypeptide comprising an extracellular ligand-binding domain of an fc� receptor capable of binding an fc ligand and an amino acid sequence capable of recruiting said first polypeptide such that upon binding of said fc ligand to said extracellular ligand-binding domain of said fc� receptor said activating signal is transmitted.

Inventor(s): Yaron CARMI, Peleg RIDER, Diana RASOULOUNIRIANA

CPC Classification: C07K14/70535 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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