THERAPEUTIC REGIMENS FOR CHIMERIC ANTIGEN RECEPTOR (CAR)-EXPRESSING CELLS

Abstract: the invention provides a method of treating an adult subject having a hematological cancer, comprising administering to the subject selected dosage regimens comprising a plurality of immune effector cells expressing a car molecule.

Inventor(s): David L. Porter, Noelle Frey, Carl H. June, Simon Lacey, Fang Chen, Jan J. Melenhorst, Tetiana Taran, Karen Thudium Mueller, Patricia Wood, Yiyun Zhang

CPC Classification: C07K14/705 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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