HETEROBIFUNCTIONAL TARGETED PROTEIN DEGRADERS

Abstract: the present disclosure relates to compounds that bind to the kelch domain-containing protein 2 (klhdc2) e3 ligase active site and heterobifunctional targeted protein degraders comprising the compounds. methods of using these degraders in the treatment of cancer is also described. this abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Inventor(s): Richard E. Lee, Suresh Dharuman, Daniel C. Scott, Jason M. Ochoada, Rajendra P. Tangallapally, Brenda A. Schulman

CPC Classification: C07D495/14 (HETEROCYCLIC COMPOUNDS (macromolecular compounds ))

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