20250163064. Quinazoline Compounds Uses Ther (AMGEN .)
QUINAZOLINE COMPOUNDS AND USES THEREOF AS INHIBITORS OF MUTANT KRAS PROTEINS
Abstract: the present disclosure provides compounds useful for the inhibition of kras g12d, g12v, g12a, g12s or g12c. the compounds have a general formula i: (i) wherein the variables of formula i are defined herein. this disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.
Inventor(s): Brian Alan Lanman, Ryan Paul Wurz, Wei Zhao, Xiaofen LI, Michael YAMANO, Imelda HOT, Rene RAHIMOFF, Liping Pettus, Jose Medina
CPC Classification: C07D487/04 (Ortho-condensed systems)
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Categories:
- Patent Applications
- AMGEN INC.
- CPC C07D487/04
- Brian Alan Lanman of Woodland Hills CA US
- Ryan Paul Wurz of Newbury Park CA US
- Wei Zhao of Westford MA US
- Xiaofen LI of Thousand Oaks CA US
- Michael YAMANO of Thousand Oaks CA US
- Imelda HOT of Thousand Oaks CA US
- Rene RAHIMOFF of Santa Monica CA US
- Liping Pettus of Thousand Oaks CA US
- Jose Medina of Thousand Oaks CA US