TRANSGLUTAMINASE CONJUGATION METHOD AND LINKER

Abstract: the present invention relates to a method for generating an antibody-payload conjugate by means of a microbial transglutaminase (mtg). the method comprises a step of conjugating a linker having a primary amine residue, said linker having the peptide structure (shown in n→c direction) (aax)-(aax)(nh)-(aax)-b-(aax), or (aax)-b-(aax)-(aax)(nh)-(aax), to a gln residue comprised in the heavy or light chain of an antibody. aax(nh) is an amino acid, amino acid derivative or amino acid mimetic comprising a side chain having a primary amine group

Inventor(s): Philipp SPYCHER, Roger SCHIBLI, Martin BEHE, Jori WEHRMULLER

CPC Classification: A61K47/6889 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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