POLYSUBUNIT OPIOID PRODRUGS RESISTANT TO OVERDOSE AND ABUSE

Abstract: the invention provides compositions and methods for the treatment or prevention of pain. compositions provided are resistant to overdose and abuse. compositions provided comprise two or more different molecules, where each molecule comprises at least one gi enzyme-labile opioid agonist releasing subunit comprising an opioid agonist that is covalently linked to at least one gi enzyme inhibitor subunit.

Inventor(s): Thomas E. Jenkins, Craig O. Husfeld

CPC Classification: A61K47/64 (Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent (peptidic linkers ))

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