IMMUNOGENIC COMPOSITIONS COMPRISING A RECOMBINANT NEURAMINIDASE AND CpG OLIGONUCLEOTIDE ADJUVANT, AND USES THEREOF

Abstract: in one aspect, provided herein are immunogenic compositions comprising cpg oligonucleotide adjuvant, and a recombinant neuraminidase, wherein the recombinant neuraminidase comprises a globular head domain of influenza virus neuraminidase and a tetramerization domain, and wherein the recombinant neuraminidase lacks influenza virus neuraminidase stalk, transmembrane and cytoplasmic domains. in another aspect, provided herein are methods of immunizing a subject against influenza virus using such immunogenic compositions. in another aspect, provided herein are methods of immunizing a subject against influenza virus using such immunogenic compositions.

Inventor(s): Florian KRAMMER, Peter PALESE, Adolfo GARCIA-SASTRE, John D. CAMPBELL, Paula TRAQUINA, Robert L. COFFMAN

CPC Classification: A61K39/145 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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