USE OF NOVEL POMALIDOMIDE DERIVATIVE FOR TREATING BRAIN DISEASES

Abstract: the disclosure relates to compositions and methods of using a pomalidomide derivative that exhibits improved pharmacological effects as compared to pomalidomide for treating brain diseases. the pomalidomide derivative exhibits excellent binding to cereblon, has almost no cytotoxicity, is unlikely to cause teratogenic adverse effects, can control tnf-� expression, exhibits excellent in vivo pharmacokinetic stability while suppressing oxidative stress, ameliorates a decrease in motor function which is a symptom of parkinson's disease, and increases tyrosine hydroxylase expression which is reduced by parkinson's disease, and thus can be used for preventing or treating brain diseases such as parkinson's disease.

Inventor(s): Dong Seok KIM, Inho HWANG, Sun KIM

CPC Classification: A61K31/454 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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